Showing posts with label Clinical Trials. Show all posts
Showing posts with label Clinical Trials. Show all posts

Thursday, April 2, 2009

Urinary Tract Infection – 4 Alternative Treatments

According to a National Institute of Health publication, about 14.8 million women and men experienced a UTI in 1995, and with the infections' propensity to recur, especially in women, can some alternative medicine treatments be helpful too?

Urinary tract infections being the second most common type of infections affecting people, accompanies symptoms such as pain/burning while passing water, fever, tiredness/shakiness, urge to use the toilet often, etc. Doctors usually prescribe genitourinary drugs to kill the infection and a relief can be experienced, usually in a day or two.

Following are some natural remedies used on UTI sufferers.

1. Forskolin: This is an extract from the Indian coleus plant. And researchers at the Duke University Medical Center experimenting on mice found that it helps by flushing out hiding colonies of bacteria from the urinary tract. As a result make bacteria susceptible to antibiotic medications. The study appeared in the April 8, 2007 issue of the journal Nature Medicine.

2. Cranberry: According to a study from the Journal of Medicinal Food - a peer-reviewed journal, it's the chemicals present in cranberries rather than the acidity of cranberry juice that prevent infectious bacteria from attaching to urinary tract's cell lining. Further, a National Center for Complementary and Alternative Medicine (NCCAM) article suggests that some studies testing the efficacy of cranberry products in forestalling UTIs have shown promise. At the same time the results can't be considered conclusive.

3. Echinacea Purpurea: Often known as the purple coneflower, this herb has been used on urinary tract infection sufferers, either based on tradition or scientific theories. However, a National Library of Medicine article informs that this use hasn't been thoroughly tested in humans. Also, the safety and effectiveness too hasn't been proven for such use, always.

4. Probiotics: Also known as "friendly bacteria" or "good bacteria," these refer to live microorganisms that don't generally harm people. According to a conference report released in November 2005, an assessment of the use of probiotics to prevent and treat infections of the urinary tract or the female genital tract had turned out promising evidence. The conference was cofunded by the National Center for Complementary and Alternative Medicine (NCCAM) and convened by the American Society for Microbiology.

With the UTI's burdening the healthcare system with over $2 billion in treatment costs (annual), if alternative medications can complement conventional treatments in fighting it, then they should be more than welcome.

Posts, Possibly of Interest

Type 2 Diabetes & 6 Alternative Medicines

The Links Between Vegetables, Fruits and Cancer

IBS Treatment - Therapies That Work

How Simply Writing Can Help Cancer Patients

Tuesday, March 31, 2009

6 Alternative Medicines For Type 2 Diabetes

With over 200 million people suffering from diabetes worldwide, and counting, it's fast becoming the #1 epidemic of modern times. A major cause of end-stage renal disease, preventable amputations and blindness, the efficacy of many alternative medicine treatments in managing diabetes has been explored.

While conventional medicine has prescriptions of endocrine disorder drugs for diabetes, alternative therapeutic approaches to its management include herbs, plant extracts and more.

The following are some naturals and alternative therapeutics that seem promising to scientists studying their effect on diabetes.

1. Fenugreek: This herb is commonly used for appetite loss, and to stimulate milk production in breastfeeding women. And a handful of studies have discovered that fenugreek may help in bringing down blood sugar levels in diabetes sufferers, that's according to the National Center for Complementary and Alternative Medicines (NCCAM).

Some time back, the Diabetes UK referred to several herbs being studied, including momordica cymbalaria, gymnema sylvestre and swertia chirayita.

2. Momordica Cymbalaria Roots: This a cucumber-like vegetable was assessed by scientists for its effect on Type 2 diabetes control and their tests on diabetic rats showed an improved glucose tolerance.

3. Gymnema Sylvestre Herb: Originating from the Indian tropical forests, this herb when tested for its effects on the body's ability to produce insulin, seemed to have a direct impact on the pancreatic insulin producing cells.

4. Swertia Chirayita Bark: Laboratory studies on the bark have found that some compounds separated from it appear to set off insulin production, in addition to enhancing its action.

5. Berberine: Chemically classified as a salt and found in the roots and barks of many plants, it has been documented in Chinese literature for having glucose lowering properties. According to Research Australia, the compound is indeed able to help lower blood sugar levels in animal models of diabetes.

6. Tai Chi Exercises:
This isn't quite a herb, nonetheless, according to the April 2008 issue of the British Journal of Sports Medicine, Tai Chi exercises can improve the management of type 2 diabetes via improving blood glucose levels.

Despite appearing promising, experts believe that a lot more research is needed to definitively establish some of these alternative medicines' degree of efficacy.

Wednesday, March 25, 2009

IBS Treatment - Therapies That Work

Also known as spastic colon, Irritable Bowel Syndrome or IBS is a disorder of the bowel that affects about 30% people sometime during their lives. And about 10% are so much troubled by it that they seek medical help.

Some common IBS symptoms include abdominal pain, stomach cramps, constipation, diarrhea, bloated stomach, dizziness, nausea, and backaches, which cause many people to miss work, and restrict their social lives. While IBS treatments generally include a prescription of gastrointestinal drugs and changes in diet, some therapies other than conventional treatments have shown promise.

4 Treatments that work

1. Fiber, antispasmodics, and peppermint oil

A study published on bmj.com in November 2008, suggests that doctors' recommendations as first-line treatments for ibs should include fiber, antispasmodics, and peppermint oil. Because research found that patients treated with a combination of these there fared better than those who were treated with placebos or weren't treated at all. Also, no serious side effects were found. And treatment with peppermint oil appeared to be the most effective.
2. Probiotics

A set of studies presented at the American College of Gastroenterology's (ACG) 73rd Scientific Meeting indicated that probiotics were safe and effective for the treatment of constipation/diarrhea linked to Irritable Bowel Syndrome (IBS). While probiotics were found to be effective, it couldn't be concluded whether just one probiotic was enough or a combination would work better. Nonetheless, it works.

3. Cognitive Behavioral Therapy and Hypnotherapy

A study is appearing in the July 2008 issue of the journal Clinical Gastroenterology and Hepatology observes symptom relief in IBS sufferers following a self-administered, at-home cognitive behavioral program. The efficacy of the at-home program was similar to 10-week in-office program under a trained therapist's guidance. An earlier research published in the Digestive Disease Week 2006, showed cognitive behavioral therapy and hypnotherapy as effective IBS treatments that also helped in other chronic disorders of the gastrointestinal tract.

4. Traditional Chinese, Tibetan And Indian Herbal Medicines

Research appearing in the “The Cochrane Database of Systematic Reviews 2006,” suggests that traditional herbal medicines can improve abdominal pain, disturbed bowel movements, and/or bloating and distension associated with Irritable Bowel Syndrome (IBS). In the researchers' assessment spanning 75 different randomized trials, they concluded that there was evidence that some of the alternative medicines did help improve the global symptoms of IBS.

The University of Michigan advises on some dietary changes that many patients have found helpful, they include:
  • Avoid or limit the amount of gas-producing foods such as beans, onions, broccoli, cabbage or any other foods that will commonly aggravate IBS symptoms.
  • Try to slow down when you eat and avoid overeating.
  • Avoid carbonated drinks. These can introduce gas into the intestines and cause bloating or abdominal discomfort.
  • Intolerance to milk sugar, or lactose, is seen in up to 40 percent of patients with IBS. Avoiding dairy products may be helpful in reducing symptoms of IBS such as gas, bloating, cramping and diarrhea.
  • Avoid large quantities of other sugars such as fructose or sorbitol which can also worsen IBS symptoms
  • The addition of fiber in the form of psyllium can help with constipation related symptoms in IBS patients.

Thursday, March 12, 2009

Can Heart Attacks be Predicted to Save Lives?

About one of every five deaths in the United States are attributed to heart diseases. However, scientists may now well be on their way to make heart attack prediction possible so that many lives can be saved.

Heart disease is term used for a range of different diseases affecting the heart. They are often treated by surgery and cardiovascular drugs.

Even though from 1995 to 2005 the death rate from heart disease declined 34 percent, there still is a lot of potential for it to decrease further with the aid of technology. A device is being tested to monitor the heart and raise a red flag in time so that early help can be sought.

The Life Saving Technology

Called the AngelMed Guardian system, the device is about the size of a standard pacemaker is meant to be installed inside the skin close to the collarbone with a wire placed in the right chamber of the heart.

It comprises an external telemetry device and and a programmer meant to help the medics assess the heart signals. The job of the device will be to monitor a person's heart's activity for signs that may indicate an impending heart attack.

As soon as the implanted diagnostic equipment finds that something's gone amiss inside the heart, making use of Bluetooth technology and pagers, it will sound an alert to others so that quick medical attention can be provided to the patient. Also, the more disturbing or acute the symptoms of an upcoming heart attack, stronger the alert this device transmits.

According to experts, the maximum damage to the heart occurs during the first two hours after a coronary gets blocked during a heart attack. And most of the time patients take about three hours to recognize an oncoming heart attack, so help often reaches late to the sufferers. However, the unique ability of this device is that it can recognize the warning signs and sound an alert hours before the attack actually occurs thus helping doctors save lives.

Still undergoing Phase II clinical trials, if all goes well then it may actually be able to predict heart attacks and save lives.

Posts, Possibly of Interest

Top 15 Tips to Manage Stress!

Video Game Surgery – A New Way To Train Surgeons

Medical Device Industry Overview

Pee on Paper to Treat TB – Here's How?

Gold Particles Could Deliver Pharma Drugs in Future!

Thursday, February 26, 2009

Now Magnets May Drive Reflux Disease Away

An estimated 20 million Americans suffer from gastroesophageal reflux disease (GERD), which causes a person to experience chronic heartburn. While medical drugs helps manage the condition in the short-term, longer term relief sometimes requires surgery. But could a long term solution to the problem be hidden in modest looking magnets?

A common cause of gastroesophageal reflux disease or (GERD) is a weak or nonfunctional valve at the lower end of the esophagus (the canal that connects the mouth to the stomach), as a result the acids inside the stomach make their way into the esophagus. Since the esophagus or the food pipe isn't designed to withstand acids, the patient experiences chronic heartburn. But medics are now testing a new device which could support the function of the malfunctioning valves to treat the disease.

The New Reflux Control Device

Called the LINX Reflux Management System and introduced by Torax Medical, this device comprises a series of magnetic beads, and is meant to be placed around the bottom of the esophagus through a minimally-invasive surgical procedure, using medical instruments.

Once positioned, the magnetic attraction between the beads work in tandem with the valve and help prevent the acids to reflux, or rush up the esophagus. At the same time, the system is designed to allow food to normally pass through the esophagus to the stomach. Which is exactly what a healthy valve's function is.


According to experts, when medical therapy alone is used to treat GERD, the acids in the stomach are simply suppressed, but the underlying problem of reflux isn't cured. As a result, the most appropriate and lasting treatment for GERD would be to restore the body's own ability to avoid reflux itself.

While the new magnetic device is still being clinically tried, its real success might eventually depend on how effective it will be in comparison to other surgical procedures viz. open and Nissen fundoplications that are sometimes indicated for treating GERD.

Post, Possibly of Interest

Medical Device Industry Overview

Video Game Surgery – A New Way To Train Surgeons

Recession and Prescription Drug Abuse

Pee on Paper to Treat TB – Here's How?

Friday, January 30, 2009

Study: Stem Cell Transplant Reverses Multiple Sclerosis

Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems.

"This is the first time we have turned the tide on this disease," said principal investigator Richard Burt, M.D. chief of immunotherapy for autoimmune diseases at the Feinberg School. The clinical trial was performed at Northwestern Memorial Hospital where Burt holds the same title.

The patients in the small phase I/II trial continued to improve for up to 24 months after the transplantation procedure and then stabilized. They experienced improvements in areas in which they had been affected by multiple sclerosis including walking, ataxia, limb strength, vision and incontinence. The study will be published online January 30 and in the March issue of The Lancet Neurology.

"We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy with cancer drugs," Burt said. After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system.

"In MS the immune system is attacking your brain," Burt said. "After the procedure, it doesn't do that anymore."

In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. "It didn't help in the late stages, but when we treat them in the early stage, they get better and continue to get better," he said.

Source: EurekAlert!

Posts, Possibly of Interest

FDA: Skin Numbing Products Can Be Life Threatening

Top 13 Tips To Prevent Common Cold!

Vicks VapoRub Misuse May Harm Toddlers

Financial Crisis – Survival Tips for Small Medical Businesses

Thursday, January 15, 2009

Atypical Antipsychotic Drugs Increase Risk Of Sudden Cardiac Death In Adults

Patients ages 30 to 74 who took atypical antipsychotic pharmaceutical drugs such as risperidone (sold as Risperdal), quetiapine (Seroquel), olanzapine (Zyprexa) and clozapine (Clozaril) had a significantly higher risk of sudden death from cardiac arrhythmias and other cardiac causes than patients who did not take these medications, according to a new study funded by HHS' Agency for Healthcare Research and Quality. The risk of death increased with higher doses of the drugs taken.

The study, titled "Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death," is published in the January 15 issue of the New England Journal of Medicine.

Atypical antipsychotics are commonly used to treat schizophrenia and bipolar disorders. They are also prescribed "off label" for symptoms such as agitation, anxiety, psychotic episodes and obsessive behaviors. Atypical antipsychotics are less likely to cause tremors and other serious movement disorders that affect users of typical antipsychotics.

"This study provides critical information about the safety of atypical antipsychotics that can be used to make important treatment decisions for patients," said AHRQ Director Carolyn M. Clancy, M.D. "These findings will help clinicians and patients weigh the risks versus the benefits of these drugs before prescribing them for treatment of depression or other off label uses for other conditions."

Lead researcher Wayne A. Ray, Ph.D., and his colleagues at AHRQ's Center for Education and Research on Therapeutics at Vanderbilt University in Nashville found that current users of atypical antipsychotic drugs had a rate of sudden cardiac death twice that of people who didn't use the drugs and similar to the death rate for patients taking typical antipsychotics, including haloperidol (Haldol) and thioridazine (Mellaril).

Researchers reviewed medical records from the Tennessee Medicaid program and identified data on patients prescribed atypical antipsychotics, including the number of prescriptions they received, the dose and the number of days supplied. Researchers conclude that atypical antipsychotics are not a safer alternative to typical antipsychotics in preventing death from sudden cardiac causes.

The CERTs program, established in 1999, is a research program administered by AHRQ in consultation with the U.S. Food and Drug Administration. The overarching goal is to serve as a trusted national resource for people seeking to improve health through the best use of medical therapies. The CERTs program includes partnerships of public and private organizations, a national steering committee involving multiple sectors and the CERTs investigators, a coordinating center and 14 research centers.

Source: AHRQ

Posts, Possibly of Interest

Vicks VapoRub Misuse May Harm Toddlers

Bad Drug Combo Risk - Seniors Are Not Alone

California's Autism Cases Rising!

Vaccines – The Invaluable Pharmaceuticals

Tuesday, December 16, 2008

Phony Patients may Avert Adverse Drug Events

On May 20, 1999 Rofecoxib, better known as “Vioxx,” was approved as safe and effective by the Food and Drug Administration (FDA), on September 30, 2004, the manufacturer voluntarily recalled the drug from the market because of concerns of increased risk of heart attack and stroke.

Clinical trials or drug testing, a pharmaceutical service, is complex. And while the criticism of the US FDA over monitoring of product safety continues, there may already exist solutions that may help the federal agency to better prevent similar debacles from recurring.

The Virtual Patient Platform

One such predictive computer model of human physiology is known as the Cardiovascular PhysioLab(R). Developed by Entelos, this platform can aid in drug discovery and development by offering a comprehensive large-scale computer simulation of cholesterol regulation, atherogenesis, and cardiovascular risk.

In fact, it may also help evaluate combination therapies, identify and interpret biomarker patterns, and predict a drug's long-term clinical efficacy in managing cholesterol, atherosclerosis, and heart disease.

Heart disease is the leading cause of death for both women and men in the United States. For instance, in 2002, 696,947 people died of heart disease, about half of them women. This is a big number because it made up for 29% of all U.S. deaths.

Now, while these man-made patients might serve as a powerful and innovative means towards diagnosis, treatment, monitoring and prevention of complex, chronic diseases, modern controlled clinical trials are still the best way for evaluating safety and efficacy of drugs, according to pharmaceutical service industry experts.

Nevertheless, technology such as this which enables a broad range of "virtual patients" to be tried for different drugs, does seem to make the job of drug development easy and safe. Perhaps with time as the technology advances, it may include many more functions, reducing dependence on human subjects. Making it even safer.

And to the FDA, it might provide an invaluable tool to better monitor ongoing cardiovascular trials before their submission for approval, and also help it to determine possible adverse events in advance. Possibly preventing another drug debacle like the one from the past.

Posts, Possibly of Interest

Video Game Surgery – A New Way To Train Surgeons

Sick (Man)nequin – A New Way To Train Medics

Chemical War Agents – A New Way of Decontamination