Wednesday, August 20, 2008

Drug Resistant Diseases: Taming Of The Shrew

Exceedingly detested but true, when diseases once treatable cease to respond to pharmaceutical drugs, the consequences can be devastating. However, things could change if the scientists succeed in successfully testing a newly developed mechanism to thwart drug resistance.

It's impossible to talk of drug resistance and not mention the super bug, “Staphylococcus aureus.” Often it's the bacteria that come to ones mind when you think drug resistance, but sometimes it can be other pathogens such as cancer cells. However, now researchers seem to be attempting to bluff these pathogenic cells to get potent medicine inside them, thus spelling their doom.

How The New Process Works?

One way by which resistance develops is when the pathogenic cells suddenly become clever (and cunning and @#$) and don't let medicines seep through their skin and act against them. But taking a lead from nature the Stanford University have developed a method to combat this common form of resistance.

The solution formulated by scientists centers around the compound “Arginine,” an amino acid (amino acids are the building blocks of proteins) abundantly found in cells. As against other substances, when arginine rich compounds try to enter a cell they are welcomed, even by resistant cells.

So now the tactic used entails cloaking the therapeutic compound with Arginine, hence facilitating its entry into the target cell. Once the Arginine bounded medicine gets inside it only needs to broken apart from Arginine (the cloak) to begin its action. And this is achieved by glutathione, a molecule naturally present inside a cell. After the temporary and weak medicine---Arginine complex is broken down, the pathogenic cell has no choice but to succumb.

For now the mechanism has been successfully tested with the ovarian cancer drug “Paclitaxel,” however it can have applications in bacterial diseases as well, viz. multi-drug resistant tuberculosis, the scientists have suggested.

Another promising find of the study was that the scientists can control even the rate at which the medicine is release by tweaking “Arginine” just a little bit. And that's not all, a cancer therapy based on this technique even promises a treatment with lesser negative side effects that go along with chemotherapy.

While cancer drugs are just one example, come to think of if most drug resistant diseases can be tackled in this manner, health would be restored to millions who suffer due to this type of drug resistance. Buck Up! The medical industry

In addition, I think that off late, pure naturals have also shown promise against two challenging, diabetes and cancer. View the following posts to know more.

The Power Naturals Against Diabetes &

The Power of Naturals Against Cancer

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